George Clooney shows his humorous side in a commercial for a new tequila called "It Could Happen, Please Drink Responsibly."

The Casamigos Tequila ad, which also features Cindy Crawford, her husband Rande Gerber and Clooney squeeze Stacy Keibler was filmed at one of Clooney's homes and is said to be "loosely based on a true story."  Oh my!  It's worth a minute and a half out of your day to watch.  Too funny.

I'm guessing no one drank responsibly.