Colin Kaepernick threw for 235 yards and three touchdowns, and the San Francisco 49ers cruised past the Washington Redskins, 27-6, on Monday night in Landover, Md.
Cam Newton threw a 25-yard touchdown pass to Ted Ginn Jr. with 59 seconds to play, and the Carolina Panthers beat the New England Patriots, 24-20, in Charlotte on Monday night.
The AFC's best teams clash in Denver and several other playoff contenders meet in colossal NFL showdowns. Here are five storylines we're watching this week: